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Somatic mutationGenetic predispositionCarcinogenesisCancer epigeneticsGenome instabilityGermline mosaicismMosaicAntigenic driftTgf beta signaling pathwayBiogerontologyImmortalised cell lineDegenerative diseaseCellular adaptationSomatic cell nuclear transferSomatic hypermutationCellular stress responseGenotoxicityGene signatureClonal selectionGene therapySignal transductionBiomarkerBase excision repairMolecular diagnosticsBone remodelingCancer syndromeTumour heterogeneityDe novo mutationField cancerizationAutocrine signalingHayflick limitRegenerative medicineCell damageAutoimmunityChromothripsisMucolipidosisEnduranceAdaptive immune systemHealingChromatin remodelingDna damage theory of agingHallmarks of agingCancer stem cellNatural history of diseaseAmitosisEpithelial dysplasiaCauses of cancerMalignant transformationRibosomal frameshiftCopy number variationMultifactorial diseaseInduced stem cellsGain-of-function researchMicrosatellite instabilityTissue engineeringParacrine signalingRna editingEpigenetics of depressionHeat shock responsePathophysiologyDna mismatch repairSplice site mutationDysplasiaFree-radical theory of agingInborn errors of metabolismReceptor-mediated endocytosisParaneoplastic syndromeInhibitor of apoptosisEvolutionary medicineBiological immortalityClonal hematopoiesisAnticipationCancer cellAllostatic loadNatural reservoirIntestinal metaplasiaMolecular pathologyFibrosisProgrammed cell deathAutophagyChronic liver diseaseOxidative stressLangerhans cell histiocytosisProtein aggregationHousekeeping geneCoenocyteCancer immunologyCompound heterozygosityGenetic discriminationHaemodynamic responseHaematopoiesisBiotic stressClinical pathologyNeurofibromatosis type iImmunogeneticsDysbiosisGaucher's diseasePathogen transmissionHuman germline engineeringExon skipping